Coming Soon - Manuscripts available at bioRxiv:
Juliane Winkler, Weilun Tan, Catherine M. M. Diadhiou, Christopher S. McGinnis, Aamna Abbasi, Saad Hasnain, Sophia Durney, Elena Atamaniuc, Daphne Superville, Leena Awni, Joyce V. Lee, Johanna H. Hinrichs, Marco Y. Hein, Michael Borja, Angela Detweiler, Su-Yang Liu, Ankitha Nanjaraj, Vaishnavi Sitarama, Hope S. Rugo, Norma Neff, Zev J. Gartner, Angela Oliveira Pisco, Andrei Goga, Spyros Darmanis, Zena Werb
Dissecting the contributions of tumor heterogeneity on metastasis at single-cell resolution
doi: https://doi.org/10.1101/2022.08.04.502697
www.biorxiv.org/content/10.1101/2022.08.04.502697v1
Albertas Navickas, Hosseinali Asgharian, Juliane Winkler, Lisa Fish, Kristle Garcia, Daniel Markett, Martin Dodel, Bruce Culbertson, Sovit Miglani, Tanvi Joshi, Phi Nguyen, Steven Zhang, Nicholas Stevers, Hun-Way Hwang, Faraz Mardakheh, Andrei Goga, Hani Goodarzi
An mRNA processing pathway suppresses metastasis by governing translational control from the nucleus.
bioRxiv 2021.10.04.463118; doi: https://doi.org/10.1101/2021.10.04.463118
https://www.biorxiv.org/content/10.1101/2021.10.04.463118v1
Roman Camarda, Jeremy Williams, Serghei Malkov, Lisa J Zimmerman, SuzanneManning, Dvir Aran, Andrew Beardsley, Daniel Van de Mark, Yong Chen, Charles ABerdan, Sharon M Louie, Celine Mahieu, Juliane Winkler, Elizabeth Willey, John DGagnon, Kosaku Shinoda, Karl Mark Ansel, Zena Werb, Daniel K Nomura, ShingoKajimura, Atul J Butte, Melinda E Sanders, Daniel C Liebler, Hope Rugo, GregorKrings, John A Shepherd, Andrei Goga
Tumor cell-adipocyte gap junctions activate lipolysis and are essential for breast tumorigenesis.
bioRxiv 277939; doi: https://doi.org/10.1101/277939
www.biorxiv.org/content/10.1101/277939v1.full
Peer Reviewed Manuscripts:
Bui TBV, Burgering BMT, Goga A, Rugo HS, van 't Veer LJ.
Biomarkers for Cyclin-Dependent Kinase 4/6 Inhibitors in the Treatment of Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Negative Advanced/Metastatic Breast Cancer: Translation to Clinical Practice.
JCO Precis Oncol. 2022 Jun;6:e2100473. doi: 10.1200/PO.21.00473. PMID: 35666959.
https://pubmed.ncbi.nlm.nih.gov/35666959/
pubmed.ncbi.nlm.nih.gov/35666959/
Lee JV, Housley F, Yau C, Nakagawa R, Winkler J, Anttila JM, Munne PM, Savelius M, Houlahan KE, Van de Mark D, Hemmati G, Hernandez GA, Zhang Y, Samson S, Baas C, Esserman LJ, van 't Veer LJ, Rugo HS, Curtis C, Klefström J, Matloubian M, Goga A
Combinatorial immunotherapies overcome MYC-driven immune evasion in triple negative breast cancer
Nat Commun. 2022 Jun 27;13(1):3671. doi: 10.1038/s41467-022-31238-y
https://pubmed.ncbi.nlm.nih.gov/35760778/
Vidula N, Greenberg S, Petrillo L, Hwang J, Melisko M, Goga A, Moasser M, Magbanua M, Park JW, Rugo HS.
Evaluation of disseminated tumor cells and circulating tumor cells in patients with breast cancer receiving adjuvant zoledronic acid.
NPJ Breast Cancer. 2021 Sep 6;7(1):113. doi: 10.1038/s41523-021-00323-8. PMID: 34489453; PMCID: PMC8421499.
https://pubmed.ncbi.nlm.nih.gov/34489453/
Samson S, Northey JJ, Acerbi I, Goga A, Flink CL, Weaver VM, LaBarge MA.
NCI's publication affiliation conundrum: Reframing innovation to incentivize an equitable path for advocate representation.
Transl Oncol. 2022 Feb;16:101325. doi: 10.1016/j.tranon.2021.101325. Epub 2021 Dec 30. PMID: 34974281; PMCID: PMC8728534.
https://pubmed.ncbi.nlm.nih.gov/34974281/
Li Z, Ferguson L, Deol KK, Roberts MA, Magtanong L, Hendricks JM, Mousa GA, Kilinc S, Schaefer K, Wells JA, Bassik MC, Goga A, Dixon SJ, Ingolia NT, Olzmann JA.
Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability.
Nat Chem Biol. 2022 Jul;18(7):751-761. doi: 10.1038/s41589-022-01033-3. Epub 2022 May 30. PMID: 35637349; PMCID: PMC9469796.
https://pubmed.ncbi.nlm.nih.gov/35637349/
Deng N, Minoche A, Harvey K, Li M, Winkler J, Goga A, Swarbrick A.
Deep whole genome sequencing identifies recurrent genomic alterations in commonly used breast cancer cell lines and patient-derived xenograft models.
Breast Cancer Res. 2022 Sep 24;24(1):63. doi: 10.1186/s13058-022-01540-0. PMID: 36153537; PMCID: PMC9509640.
https://pubmed.ncbi.nlm.nih.gov/36153537/
Spanogiannopoulos P, Kyaw TS, Guthrie BGH, Bradley PH, Lee JV, Melamed J, Malig YNA, Lam KN, Gempis D, Sandy M, Kidder W, Van Blarigan EL, Atreya CE, Venook A, Gerona RR, Goga A, Pollard KS, Turnbaugh PJ.
Host and gut bacteria share metabolic pathways for anti-cancer drug metabolism.
Nat Microbiol. 2022 Oct;7(10):1605-1620. doi: 10.1038/s41564-022-01226-5. Epub 2022 Sep 22. PMID: 36138165; PMCID: PMC9530025.
https://pubmed.ncbi.nlm.nih.gov/36138165/
Seda Kilinc, Rebekka Paisner, Roman Camarda, Suprit Gupta, Olga Momcilovic, Rebecca A. Kohnz, Noelle D. L'Etoile, Rushika M. Perera, Daniel K. Nomura, Andrei Goga
Oncogene-Regulated Release of Extracellular Vesicles.
Dev. Cell. 2021 June 11 doi: https://doi.org/10.1016/j.devcel.2021.05.014
https://www.cell.com/developmental-cell/fulltext/S1534-5807(21)00443-3?rss=yes
Madonna, MC, Duer, JE, Lee, JV, Williams, J, Avsaroglu, B, Zhu, C, Deutsch, R, Wang, R, Crouch, BT, Hirschey, MD, Goga, A, Ramanujam, N.
In Vivo Optical Metabolic Imaging of Long-Chain Fatty Acid Uptake in Orthotopic Models of Triple-Negative Breast Cancer.
Cancers (Basel). 2021 Jan 5;13(1):148-134. doi: 10.3390/cancers13010148
pubmed.ncbi.nlm.nih.gov/33466329/
Komoll, RM, Hu Q, Olarewaju O, von Döhlen L, Yuan Q, Xie Y, Tsay HC, Daon J, Qin R, Manns MP, Sharma AD, Goga A, Ott M, Balakrishnan A.
MicroRNA-342-3p is a potent tumor suppressor in hepatocellular carcinoma.
J Hepatol. 2021 Jan 74(1):122-134. doi: 10.1016/j.jhep.2020.07.039. Epub 2020 Jul 30
pubmed.ncbi.nlm.nih.gov/32738449/
Rohrberg J, Van de Mark D, Amouzgar M, Lee JV, Taileb M, Corella A, Klinic S, Williams J, Jokisch M, Camarda R, Balakrishnan S, Shankar R, Zhou A, Chang AN, Chen B, Rugo,HS, Dumont S, Goga A.
MYC dysregulates mitosis, revealing cancer vulnerabilities.
Cell Reports. 2020 Mar10 30(10):3368-3382. doi: 10.1016/j.celrep.2020.02.041
pubmed.ncbi.nlm.nih.gov/32160543/
Shah KN, Bhatt R, Rotow J, Rohrberg J, Olivas V, Wang VE, Hemmati G, Martins MM, Maynard A, Kuhn J, Galeas J, Donnella HJ, Kaushik S, Ku A, Dumont S, Krings G, Haringsma HJ, Robillard L, Simmons AD, Harding TC, McCormick F, Goga A, Blakely CM, Bivona TG, Bandyopadhyay S.
Aurora kinase A drives the evolution of resistance to third-generation EGFR inhibitors in lung cancer.
Nat Med. 2019 Jan 25(1):111-118. doi: 10.1038/s41591-018-0264-7.
pubmed.ncbi.nlm.nih.gov/30478424/
Fish, L, Zhang S, Yu JX, Culbertson B, Zhou AY, Goga A, Goodarzi, H.
Cancer cells exploit an orphan RNA to drive.
Nat Med. 2018 Nov;24(11):1743-1751. doi: 10.1038/s41589-018-0230-4. Epub 2018 Nov 5.
pubmed.ncbi.nlm.nih.gov/30397354/
Roy S, Hooiveld GJ, Seehawer M, Caruso S, Heinzmann F, Schneider AT, Frank AK, Cardenas DV, Sonntag R, Luedde M, Trautwein C, Stein I, Pikarsky E, Loosen S, Tacke F, Ringelhan M, Avsaroglu SK, Goga A, Buendia MA, Vucur M, Heikenwalder M, Zucman-Rossi J, Zender L, Roderburg C, Luedde T.
microRNA 193a-5p Regulates Levels of Nucleolar- and Spindle-Associated Protein 1 to Suppress Hepatocarcinogenesis.
Gastroenterology. 2018 Dec;155(6):1951-1966. doi: 10.1053/j.gastro.2018.08.032. Epub 2018 Aug 27.
pubmed.ncbi.nlm.nih.gov/30165047/
Donnella HJ, Webber JT, Levin RS, Camarda R, Momcilovic O, Bayani N, Shah KN, Korkola JE, Shokat KM, Goga A, Gordan JD, Bandyopadhyay S.
Kinome rewiring reveals AURKA limits PI3K-pathway inhibitor efficacy in breast cancer.
Nat Chem Biol. 2018 Aug;14(8):768-777. doi: 10.1038/s41589-018-0081-9. Epub 2018 Jun 25.
pubmed.ncbi.nlm.nih.gov/29942081/
Nguyen QH, Pervolarakis N, Blake K, Ma D, Davis RT, James N, Phung AT, Willey E, Kumar R, Jabart E, Driver I, Rock J, Goga A, Khan SA, Lawson DA, Werb Z, Kessenbrock K.
Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity.
Nat Commun. 2018 May 23;9(1):2028. doi: 10.1038/s41467-018-04334-1.
pubmed.ncbi.nlm.nih.gov/29795293/
Samson S, Northey JJ, Plaks V, Baas C, Dean I, LaBarge MA, Goga A, Van't Veer LJ, Weaver VM.
New Horizons in Advocacy Engaged Physical Sciences and Oncology Research.
Trends Cancer. 2018 Apr;4(4):260-264. doi: 10.1016/j.trecan.2018.02.002. Epub 2018 Mar 15.
pubmed.ncbi.nlm.nih.gov/29606307/
Dvir Aran, Roman Camarda, Justin Odegaard, Hyojung Paik, Boris Oskotsky, Gregor Krings, Andrei Goga, Marina Sirota & Atul J. Butte.
Comprehensive analysis of normal adjacent to tumor transcriptomes.
Nat Commun. 2017 Oct 20;8(1):1077. doi: 10.1038/s41467-017-01027-z.
pubmed.ncbi.nlm.nih.gov/29057876/
Shin PJ, Zhu Z, Camarda R, Bok RA, Zhou AY, Kurhanewicz J, Goga A, Vigneron DB.
Cancer recurrence monitoring using hyperpolarized 13C-pyruvate metabolic imaging in murine breast cancer model.
Magnetic resonance imaging. 2017; 43:105-109.
pubmed.ncbi.nlm.nih.gov/28716678/
Milshteyn E, von Morze C, Reed GD, Shang H, Shin PJ, Zhu Z, Chen HY, Bok R, Goga A, Kurhanewicz J, Larson PE, Vigneron DB.
Development of high resolution 3D hyperpolarized carbon-13 MR molecular imaging techniques.
Magnetic resonance imaging. 2017; 38:152-162.
pubmed.ncbi.nlm.nih.gov/28077268/
Anderton B, Camarda R, Balakrishnan S, Balakrishnan A, Kohnz RA, Lim L, Evason KJ, Momcilovic O, Kruttwig K, Huang Q, Xu G, Nomura DK, Goga A.
MYC-driven inhibition of the glutamate-cysteine ligase promotes glutathione depletion in liver cancer.
EMBO reports. 2017; 18(4):569-585.
pubmed.ncbi.nlm.nih.gov/28219903/
Kessenbrock K, Smith P, Steenbeek SC, Pervolarakis N, Kumar R, Minami Y, Goga A, Hinck L, Werb Z.
Diverse regulation of mammary epithelial growth and branching morphogenesis through noncanonical Wnt signaling.
Proceedings of the National Academy of Sciences of the United States of America. 2017; 114(12):3121-3126.
pubmed.ncbi.nlm.nih.gov/28270600/
Camarda R, Williams J, Goga A.
In Vivo Reprogramming of Cancer Metabolism by MYC.
Frontiers in Cell and Developmental Biology. 2017; 5:35.
pubmed.ncbi.nlm.nih.gov/28443280/
Horiuchi D, Camarda R, Zhou AY, Yau C, Momcilovic O, Balakrishnan S, Corella AN, Eyob H, Kessenbrock K, Lawson DA, Marsh LA, Anderton BN, Rohrberg J, Kunder R, Bazarov AV, Yaswen P, McManus MT, Rugo HS, Werb Z, Goga A.
PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression.
Nature Medicine. 2016; 22(11):1321-1329.
pubmed.ncbi.nlm.nih.gov/27775705/
Kohnz RA, Roberts LS, DeTomaso D, Bideyan L, Yan P, Bandyopadhyay S, Goga A, Yosef N, Nomura DK.
Protein Sialylation Regulates a Gene Expression Signature that Promotes Breast Cancer Cell Pathogenicity.
ACS Chemical Biology. 2016; 11(8):2131-9.
pubmed.ncbi.nlm.nih.gov/27380425/
Louie SM, Grossman EA, Crawford LA, Ding L, Camarda R, Huffman TR, Miyamoto DK, Goga A, Weerapana E, Nomura DK.
GSTP1 Is a Driver of Triple-Negative Breast Cancer Cell Metabolism and Pathogenicity.
Cell Chemical Biology. 2016; 23(5):567-578.
pubmed.ncbi.nlm.nih.gov/27185638/
Camarda R, Zhou AY, Kohnz RA, Balakrishnan S, Mahieu C, Anderton B, Eyob H, Kajimura S, Tward A, Krings G, Nomura DK, Goga A. Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer.
Nature Medicine. 2016; 22(4):427-32.
pubmed.ncbi.nlm.nih.gov/26950360/
Caswell JL, Camarda R, Zhou AY, Huntsman S, Hu D, Brenner SE, Zaitlen N, Goga A, Ziv E.
Multiple breast cancer risk variants are associated with differential transcript isoform expression in tumors.
Human Molecular Genetics. 2015; 24(25):7421-31.
pubmed.ncbi.nlm.nih.gov/26472073/
Wang ES, Reyes NA, Melton C, Huskey NE, Momcilovic O, Goga A, Blelloch R, OakesSA.
Fas-Activated Mitochondrial Apoptosis Culls Stalled Embryonic Stem Cells to Promote Differentiation.
Current Biology : CB. 2015; 25(23):3110-8.
pubmed.ncbi.nlm.nih.gov/26585277/
Lawson DA, Bhakta NR, Kessenbrock K, Prummel KD, Yu Y, Takai K, Zhou A, Eyob H,Balakrishnan S, Wang CY, Yaswen P, Goga A, Werb Z.
Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells.
Nature. 2015; 526(7571):131-5.
pubmed.ncbi.nlm.nih.gov/26416748/
Kohnz RA, Mulvihill MM, Chang JW, Hsu KL, Sorrentino A, Cravatt BF, Bandyopadhyay S, Goga A, Nomura DK.
Activity-Based Protein Profiling of Oncogene-Driven Changes in Metabolism Reveals Broad Dysregulation of PAFAH1B2 and 1B3 in Cancer.
ACS Chemical Biology. 2015; 10(7):1624-30.
pubmed.ncbi.nlm.nih.gov/25945974/
Brondfield S, Umesh S, Corella A, Zuber J, Rappaport AR, Gaillard C, Lowe SW, Goga A, Kogan SC.
Direct and indirect targeting of MYC to treat acute myeloid leukemia.
Cancer Chemotherapy and Pharmacology. 2015; 76(1):35-46.
pubmed.ncbi.nlm.nih.gov/25956709/
Evason KJ, Francisco MT, Juric V, Balakrishnan S, Lopez Pazmino Mdel P, Gordan JD, Kakar S, Spitsbergen J, Goga A, Stainier DY.
Identification of Chemical Inhibitors of β-Catenin-Driven Liver Tumorigenesis in Zebrafish.
PLoS Genetics. 2015; 11(7):e1005305.
pubmed.ncbi.nlm.nih.gov/26134322/
Huskey NE, Guo T, Evason KJ, Momcilovic O, Pardo D, Creasman KJ, Judson RL, Blelloch R, Oakes SA, Hebrok M, Goga A.
CDK1 inhibition targets the p53-NOXA-MCL1 axis, selectively kills embryonic stem cells, and prevents teratoma formation.
Stem Cell Reports. 2015; 4(3):374-89.
pubmed.ncbi.nlm.nih.gov/25733019/
Martins MM, Zhou AY, Corella A, Horiuchi D, Yau C, Rakshandehroo T, Gordan JD, Levin RS, Johnson J, Jascur J, Shales M, Sorrentino A, Cheah J, Clemons PA, Shamji AF, Schreiber SL, Krogan NJ, Shokat KM, McCormick F, Goga A, Bandyopadhyay S.
Linking tumor mutations to drug responses via a quantitative chemical-genetic interaction map.
Cancer Discovery. 2015; 5(2):154-67.
pubmed.ncbi.nlm.nih.gov/25501949/
Patton JG, Franklin JL, Weaver AM, Vickers K, Zhang B, Coffey RJ, Ansel KM, Blelloch R, Goga A, Huang B, L'Etoille N, Raffai RL, Lai CP, Krichevsky AM, Mateescu B, Greiner VJ, Hunter C, Voinnet O, McManus MT.
Biogenesis, delivery, and function of extracellular RNA.
Journal of Extracellular Vesicles. 2015; 4:27494.
pubmed.ncbi.nlm.nih.gov/26320939/
Hoellein A, Fallahi M, Schoeffmann S, Steidle S, Schaub FX, Rudelius M, Laitinen I, Nilsson L, Goga A, Peschel C, Nilsson JA, Cleveland JL, Keller U.
Myc-induced SUMOylation is a therapeutic vulnerability for B-cell lymphoma.
Blood. 2014; 124(13):2081-90.
pubmed.ncbi.nlm.nih.gov/25143484/
Benjamin DI, Louie SM, Mulvihill MM, Kohnz RA, Li DS, Chan LG, Sorrentino A, Bandyopadhyay S, Cozzo A, Ohiri A, Goga A, Ng SW, Nomura DK.
Inositol phosphate recycling regulates glycolytic and lipid metabolism that drives cancer aggressiveness.
ACS Chemical Biology. 2014; 9(6):1340-50.
pubmed.ncbi.nlm.nih.gov/24738946/
Chien AJ, Munster PN, Melisko ME, Rugo HS, Park JW, Goga A, Auerback G, Khanafshar E, Ordovas K, Koch KM, Moasser MM.
Phase I dose-escalation study of 5-day intermittent oral lapatinib therapy in patients with human epidermal growth factor receptor 2-overexpressing breast cancer.
Journal of Clinical Oncology : official journal of the American Society of Clinical Oncology. 2014; 32(14):1472-9.
pubmed.ncbi.nlm.nih.gov/24711549/
Balko JM, Giltnane JM, Wang K, Schwarz LJ, Young CD, Cook RS, Owens P, Sanders ME, Kuba MG, Sánchez V, Kurupi R, Moore PD, Pinto JA, Doimi FD, Gómez H, Horiuchi D, Goga A, Lehmann BD, Bauer JA, Pietenpol JA, Ross JS, Palmer GA, Yelensky R,Cronin M, Miller VA, Stephens PJ, Arteaga CL.
Molecular profiling of the residual disease of triple-negative breast cancers after neoadjuvant chemotherapy identifies actionable therapeutic targets.
Cancer Discovery. 2014; 4(2):232-45.
pubmed.ncbi.nlm.nih.gov/24356096/
Lim L, Balakrishnan A, Huskey N, Jones KD, Jodari M, Ng R, Song G, Riordan J, Anderton B, Cheung ST, Willenbring H, Dupuy A, Chen X, Brown D, Chang AN, Goga A.
MicroRNA-494 within an oncogenic microRNA megacluster regulates G1/S transition in liver tumorigenesis through suppression of mutated in colorectal cancer.
Hepatology (Baltimore, Md.). 2014; 59(1):202-15.
pubmed.ncbi.nlm.nih.gov/23913442/
Swisher CL, Larson PE, Kruttwig K, Kerr AB, Hu S, Bok RA, Goga A, Pauly JM, Nelson SJ, Kurhanewicz J, Vigneron DB.
Quantitative measurement of cancer metabolism using stimulated echo hyperpolarized carbon-13 MRS.
Magnetic resonance in medicine. 2014; 71(1):1-11.
pubmed.ncbi.nlm.nih.gov/23412881/
Horiuchi D, Anderton B, Goga A.
Taking on challenging targets: making MYC druggable.
American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Meeting. 2014; :e497-502.
pubmed.ncbi.nlm.nih.gov/24857145/
Olive V, Sabio E, Bennett MJ, De Jong CS, Biton A, McGann JC, Greaney SK, Sodir NM, Zhou AY, Balakrishnan A, Foth M, Luftig MA, Goga A, Speed TP, Xuan Z, Evan GI, Wan Y, Minella AC, He L.
A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis.
eLife. 2013; 2:e00822.
pubmed.ncbi.nlm.nih.gov/24137534/
Juang BT, Gu C, Starnes L, Palladino F, Goga A, Kennedy S, L'Etoile ND.
Endogenous nuclear RNAi mediates behavioral adaptation to odor.
Cell. 2013; 154(5):1010-22.
pubmed.ncbi.nlm.nih.gov/23993094/
Upton JP, Wang L, Han D, Wang ES, Huskey NE, Lim L, Truitt M, McManus MT, Ruggero D, Goga A, Papa FR, Oakes SA.
IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2.
Science (New York, N.Y.). 2012; 338(6108):818-22.
pubmed.ncbi.nlm.nih.gov/23042294/
Amin DN, Sergina N, Lim L, Goga A, Moasser MM.
HER3 signalling is regulated through a multitude of redundant mechanisms in HER2-driven tumour cells.
The Biochemical Journal. 2012; 447(3):417-25.
pubmed.ncbi.nlm.nih.gov/22853430/
Horiuchi D, Huskey NE, Kusdra L, Wohlbold L, Merrick KA, Zhang C, Creasman KJ,Shokat KM, Fisher RP, Goga A.
Chemical-genetic analysis of cyclin dependent kinase 2 function reveals an important role in cellular transformation by multiple oncogenic pathways.
Proceedings of the National Academy of Sciences of the United States of America. 2012; 109(17):E1019-27.
pubmed.ncbi.nlm.nih.gov/22474407/
Horiuchi D, Kusdra L, Huskey NE, Chandriani S, Lenburg ME, Gonzalez-Angulo AM, Creasman KJ, Bazarov AV, Smyth JW, Davis SE, Yaswen P, Mills GB, Esserman LJ, Goga A.
MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition.
The Journal of Experimental Medicine. 2012; 209(4):679-96.
pubmed.ncbi.nlm.nih.gov/22430491/
von Morze C, Larson PE, Hu S, Yoshihara HA, Bok RA, Goga A, Ardenkjaer-Larsen JH, Vigneron DB.
Investigating tumor perfusion and metabolism using multiple hyperpolarized (13)C compounds: HP001, pyruvate and urea.
Magnetic resonance imaging. 2012; 30(3):305-11.
pubmed.ncbi.nlm.nih.gov/22430491/
Hu S, Balakrishnan A, Bok RA, Anderton B, Larson PE, Nelson SJ, Kurhanewicz J, Vigneron DB, Goga A.
13C-pyruvate imaging reveals alterations in glycolysis that precede c-Myc-induced tumor formation and regression.
Cell Metabolism. 2011; 14(1):131-42.
pubmed.ncbi.nlm.nih.gov/21723511/
Merrick KA, Wohlbold L, Zhang C, Allen JJ, Horiuchi D, Huskey NE, Goga A, Shokat KM, Fisher RP.
Switching Cdk2 on or off with small molecules to reveal requirements in human cell proliferation.
Molecular cell. 2011; 42(5):624-36.
pubmed.ncbi.nlm.nih.gov/21658603/
Chow EK, Zhang XQ, Chen M, Lam R, Robinson E, Huang H, Schaffer D, Osawa E, Goga A, Ho D.
Nanodiamond therapeutic delivery agents mediate enhanced chemoresistant tumor treatment.
Science Translational Medicine. 2011; 3(73):73ra21.
pubmed.ncbi.nlm.nih.gov/21389265/
von Morze C, Larson PE, Hu S, Keshari K, Wilson DM, Ardenkjaer-Larsen JH, Goga A, Bok R, Kurhanewicz J, Vigneron DB.
Imaging of blood flow using hyperpolarized [(13)C]urea in preclinical cancer models.
Journal of Magnetic Resonance Imaging : JMRI. 2011; 33(3):692-7.
pubmed.ncbi.nlm.nih.gov/21563254/
Swarbrick A, Woods SL, Shaw A, Balakrishnan A, Phua Y, Nguyen A, Chanthery Y, Lim L, Ashton LJ, Judson RL, Huskey N, Blelloch R, Haber M, Norris MD, Lengyel P, Hackett CS, Preiss T, Chetcuti A, Sullivan CS, Marcusson EG, Weiss W, L'Etoile N, Goga A.
miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN-amplified neuroblastoma.
Nature Medicine. 2010; 16(10):1134-40.
pubmed.ncbi.nlm.nih.gov/20871609/
den Hollander J, Rimpi S, Doherty JR, Rudelius M, Buck A, Hoellein A, Kremer M, Graf N, Scheerer M, Hall MA, Goga A, von Bubnoff N, Duyster J, Peschel C, Cleveland JL, Nilsson JA, Keller U.
Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state.
Blood. 2010; 116(9):1498-505.
pubmed.ncbi.nlm.nih.gov/20519624/
Yang D, Liu H, Goga A, Kim S, Yuneva M, Bishop JM.
Therapeutic potential of a synthetic lethal interaction between the MYC proto-oncogene and inhibition of aurora-B kinase.
Proceedings of the National Academy of Sciences of the United States of America. 2010; 107(31):13836-41.
pubmed.ncbi.nlm.nih.gov/20643922/
Lee JI, O'Halloran DM, Eastham-Anderson J, Juang BT, Kaye JA, Scott Hamilton O, Lesch B, Goga A, L'Etoile ND.
Nuclear entry of a cGMP-dependent kinase converts transient into long-lasting olfactory adaptation.
Proceedings of the National Academy of Sciences of the United States of America. 2010; 107(13):6016-21.
pubmed.ncbi.nlm.nih.gov/20220099/
Hu S, Lustig M, Balakrishnan A, Larson PE, Bok R, Kurhanewicz J, Nelson SJ, Goga A, Pauly JM, Vigneron DB.
3D compressed sensing for highly accelerated hyperpolarized (13)C MRSI with in vivo applications to transgenic mouse models of
cancer.
Magnetic resonance in medicine. 2010; 63(2):312-21.
pubmed.ncbi.nlm.nih.gov/20017160/
Huang TH, Wu F, Loeb GB, Hsu R, Heidersbach A, Brincat A, Horiuchi D, Lebbink RJ, Mo YY, Goga A, McManus MT.
Up-regulation of miR-21 by HER2/neu signaling promotes cell invasion.
The Journal of biological chemistry. 2009; 284(27):18515-24.
pubmed.ncbi.nlm.nih.gov/19419954/
Kaye JA, Rose NC, Goldsworthy B, Goga A, L'Etoile ND.
A 3'UTR pumilio-binding element directs translational activation in olfactory sensory neurons.
Neuron. 2009; 61(1):57-70.
pubmed.ncbi.nlm.nih.gov/19146813/
Cairo S, Armengol C, De Reyniès A, Wei Y, Thomas E, Renard CA, Goga A, Balakrishnan A, Semeraro M, Gresh L, Pontoglio M, Strick-Marchand H, Levillayer F, Nouet Y, Rickman D, Gauthier F, Branchereau S, Brugières L, Laithier V, Bouvier R, Boman F, Basso G, Michiels JF, Hofman P, Arbez-Gindre F, Jouan H, Rousselet-Chapeau MC, Berrebi D, Marcellin L, Plenat F, Zachar D, Joubert M, Selves J, Pasquier D, Bioulac-Sage P, Grotzer M, Childs M, Fabre M, Buendia MA.
Hepatic stem-like phenotype and interplay of Wnt/beta-catenin and Myc signaling in aggressive childhood liver cancer.
Cancer Cell. 2008; 14(6):471-84.
pubmed.ncbi.nlm.nih.gov/19061838/
Goga A, Benz C.
Anti-oncomir suppression of tumor phenotypes.
Molecular interventions. 2007; 7(4):199-202, 180.
pubmed.ncbi.nlm.nih.gov/17827440/
Goga A, Yang D, Tward AD, Morgan DO, Bishop JM.
Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC.
Nature Medicine. 2007; 13(7):820-7.
pubmed.ncbi.nlm.nih.gov/17589519/
Scott GK, Goga A, Bhaumik D, Berger CE, Sullivan CS, Benz CC.
Coordinate suppression of ERBB2 and ERBB3 by enforced expression of micro-RNA miR-125a or miR-125b.
The Journal of Biological Chemistry. 2007; 282(2):1479-86.
pubmed.ncbi.nlm.nih.gov/17110380/
Yang D, Goga A, Bishop JM.
RNA interference (RNAi) with RNase III-prepared siRNAs.
Methods in molecular biology (Clifton, N.J.). 2004; 252:471-82.
pubmed.ncbi.nlm.nih.gov/15017072/
Yang D, Buchholz F, Huang Z, Goga A, Chen CY, Brodsky FM, Bishop JM.
Short RNA duplexes produced by hydrolysis with Escherichia coli RNase III mediate effective RNA interference in mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America. 2002; 99(15):9942-7.
pubmed.ncbi.nlm.nih.gov/12096193/
Prior to Joining UCSF:
Moro M, Walkenhorst J, Goga A, Witte ON, Superti-Furga G.
A functional screen for regulators of the c-Abl protein tyrosine kinase.
Leukemia. 1997; 11 Suppl 3:313-5.
pubmed.ncbi.nlm.nih.gov/9209375/
Golub TR, Goga A, Barker GF, Afar DE, McLaughlin J, Bohlander SK, Rowley JD, Witte ON, Gilliland DG.
Oligomerization of the ABL tyrosine kinase by the Ets protein TEL in human leukemia.
Molecular and cellular biology. 1996; 16(8):4107-16.
pubmed.ncbi.nlm.nih.gov/8754809/
Walkenhorst J, Goga A, Witte ON, Superti-Furga G.
Analysis of human c-Abl tyrosine kinase activity and regulation in S. pombe.
Oncogene. 1996; 12(7):1513-20.
pubmed.ncbi.nlm.nih.gov/8622867/
Goga A, McLaughlin J, Afar DE, Saffran DC, Witte ON.
Alternative signals to RAS for hematopoietic transformation by the BCR-ABL oncogene.
Cell. 1995; 82(6):981-8.
pubmed.ncbi.nlm.nih.gov/7553858/
Goga A, Liu X, Hambuch TM, Senechal K, Major E, Berk AJ, Witte ON, Sawyers CL.
p53 dependent growth suppression by the c-Abl nuclear tyrosine kinase.
Oncogene. 1995; 11(4):791-9.
pubmed.ncbi.nlm.nih.gov/7651743/
Cohen L, Mohr R, Chen YY, Huang M, Kato R, Dorin D, Tamanoi F, Goga A, Afar D, Rosenberg N.
Transcriptional activation of a ras-like gene (kir) by oncogenic tyrosine kinases.
Proceedings of the National Academy of Sciences of the United States of America. 1994; 91(26):12448-52.
pubmed.ncbi.nlm.nih.gov/7809057/
Afar DE, Goga A, McLaughlin J, Witte ON, Sawyers CL.
Differential complementation of Bcr-Abl point mutants with c-Myc.
Science (New York, N.Y.). 1994; 264(5157):424-6.
pubmed.ncbi.nlm.nih.gov/8153630/
Sawyers CL, McLaughlin J, Goga A, Havlik M, Witte O.
The nuclear tyrosine kinase c-Abl negatively regulates cell growth.
Cell. 1994; 77(1):121-31.
pubmed.ncbi.nlm.nih.gov/7512450/
Afar DE, Goga A, Cohen L, Sawyers CL, McLaughlin J, Mohr RN, Witte ON.
Genetic approaches to defining signaling by the CML-associated tyrosine kinase BCR-ABL.
Cold Spring Harbor symposia on quantitative biology. 1994; 59:589-94.
pubmed.ncbi.nlm.nih.gov/7587117/
Goga A, McLaughlin J, Pendergast AM, Parmar K, Muller A, Rosenberg N, Witte ON.
Oncogenic activation of c-ABL by mutation within its last exon.
Molecular and Cellular biology. 1993; 13(8):4967-75.
pubmed.ncbi.nlm.nih.gov/8336729/
Juliane Winkler, Weilun Tan, Catherine M. M. Diadhiou, Christopher S. McGinnis, Aamna Abbasi, Saad Hasnain, Sophia Durney, Elena Atamaniuc, Daphne Superville, Leena Awni, Joyce V. Lee, Johanna H. Hinrichs, Marco Y. Hein, Michael Borja, Angela Detweiler, Su-Yang Liu, Ankitha Nanjaraj, Vaishnavi Sitarama, Hope S. Rugo, Norma Neff, Zev J. Gartner, Angela Oliveira Pisco, Andrei Goga, Spyros Darmanis, Zena Werb
Dissecting the contributions of tumor heterogeneity on metastasis at single-cell resolution
doi: https://doi.org/10.1101/2022.08.04.502697
www.biorxiv.org/content/10.1101/2022.08.04.502697v1
Albertas Navickas, Hosseinali Asgharian, Juliane Winkler, Lisa Fish, Kristle Garcia, Daniel Markett, Martin Dodel, Bruce Culbertson, Sovit Miglani, Tanvi Joshi, Phi Nguyen, Steven Zhang, Nicholas Stevers, Hun-Way Hwang, Faraz Mardakheh, Andrei Goga, Hani Goodarzi
An mRNA processing pathway suppresses metastasis by governing translational control from the nucleus.
bioRxiv 2021.10.04.463118; doi: https://doi.org/10.1101/2021.10.04.463118
https://www.biorxiv.org/content/10.1101/2021.10.04.463118v1
Roman Camarda, Jeremy Williams, Serghei Malkov, Lisa J Zimmerman, SuzanneManning, Dvir Aran, Andrew Beardsley, Daniel Van de Mark, Yong Chen, Charles ABerdan, Sharon M Louie, Celine Mahieu, Juliane Winkler, Elizabeth Willey, John DGagnon, Kosaku Shinoda, Karl Mark Ansel, Zena Werb, Daniel K Nomura, ShingoKajimura, Atul J Butte, Melinda E Sanders, Daniel C Liebler, Hope Rugo, GregorKrings, John A Shepherd, Andrei Goga
Tumor cell-adipocyte gap junctions activate lipolysis and are essential for breast tumorigenesis.
bioRxiv 277939; doi: https://doi.org/10.1101/277939
www.biorxiv.org/content/10.1101/277939v1.full
Peer Reviewed Manuscripts:
Bui TBV, Burgering BMT, Goga A, Rugo HS, van 't Veer LJ.
Biomarkers for Cyclin-Dependent Kinase 4/6 Inhibitors in the Treatment of Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Negative Advanced/Metastatic Breast Cancer: Translation to Clinical Practice.
JCO Precis Oncol. 2022 Jun;6:e2100473. doi: 10.1200/PO.21.00473. PMID: 35666959.
https://pubmed.ncbi.nlm.nih.gov/35666959/
pubmed.ncbi.nlm.nih.gov/35666959/
Lee JV, Housley F, Yau C, Nakagawa R, Winkler J, Anttila JM, Munne PM, Savelius M, Houlahan KE, Van de Mark D, Hemmati G, Hernandez GA, Zhang Y, Samson S, Baas C, Esserman LJ, van 't Veer LJ, Rugo HS, Curtis C, Klefström J, Matloubian M, Goga A
Combinatorial immunotherapies overcome MYC-driven immune evasion in triple negative breast cancer
Nat Commun. 2022 Jun 27;13(1):3671. doi: 10.1038/s41467-022-31238-y
https://pubmed.ncbi.nlm.nih.gov/35760778/
Vidula N, Greenberg S, Petrillo L, Hwang J, Melisko M, Goga A, Moasser M, Magbanua M, Park JW, Rugo HS.
Evaluation of disseminated tumor cells and circulating tumor cells in patients with breast cancer receiving adjuvant zoledronic acid.
NPJ Breast Cancer. 2021 Sep 6;7(1):113. doi: 10.1038/s41523-021-00323-8. PMID: 34489453; PMCID: PMC8421499.
https://pubmed.ncbi.nlm.nih.gov/34489453/
Samson S, Northey JJ, Acerbi I, Goga A, Flink CL, Weaver VM, LaBarge MA.
NCI's publication affiliation conundrum: Reframing innovation to incentivize an equitable path for advocate representation.
Transl Oncol. 2022 Feb;16:101325. doi: 10.1016/j.tranon.2021.101325. Epub 2021 Dec 30. PMID: 34974281; PMCID: PMC8728534.
https://pubmed.ncbi.nlm.nih.gov/34974281/
Li Z, Ferguson L, Deol KK, Roberts MA, Magtanong L, Hendricks JM, Mousa GA, Kilinc S, Schaefer K, Wells JA, Bassik MC, Goga A, Dixon SJ, Ingolia NT, Olzmann JA.
Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability.
Nat Chem Biol. 2022 Jul;18(7):751-761. doi: 10.1038/s41589-022-01033-3. Epub 2022 May 30. PMID: 35637349; PMCID: PMC9469796.
https://pubmed.ncbi.nlm.nih.gov/35637349/
Deng N, Minoche A, Harvey K, Li M, Winkler J, Goga A, Swarbrick A.
Deep whole genome sequencing identifies recurrent genomic alterations in commonly used breast cancer cell lines and patient-derived xenograft models.
Breast Cancer Res. 2022 Sep 24;24(1):63. doi: 10.1186/s13058-022-01540-0. PMID: 36153537; PMCID: PMC9509640.
https://pubmed.ncbi.nlm.nih.gov/36153537/
Spanogiannopoulos P, Kyaw TS, Guthrie BGH, Bradley PH, Lee JV, Melamed J, Malig YNA, Lam KN, Gempis D, Sandy M, Kidder W, Van Blarigan EL, Atreya CE, Venook A, Gerona RR, Goga A, Pollard KS, Turnbaugh PJ.
Host and gut bacteria share metabolic pathways for anti-cancer drug metabolism.
Nat Microbiol. 2022 Oct;7(10):1605-1620. doi: 10.1038/s41564-022-01226-5. Epub 2022 Sep 22. PMID: 36138165; PMCID: PMC9530025.
https://pubmed.ncbi.nlm.nih.gov/36138165/
Seda Kilinc, Rebekka Paisner, Roman Camarda, Suprit Gupta, Olga Momcilovic, Rebecca A. Kohnz, Noelle D. L'Etoile, Rushika M. Perera, Daniel K. Nomura, Andrei Goga
Oncogene-Regulated Release of Extracellular Vesicles.
Dev. Cell. 2021 June 11 doi: https://doi.org/10.1016/j.devcel.2021.05.014
https://www.cell.com/developmental-cell/fulltext/S1534-5807(21)00443-3?rss=yes
Madonna, MC, Duer, JE, Lee, JV, Williams, J, Avsaroglu, B, Zhu, C, Deutsch, R, Wang, R, Crouch, BT, Hirschey, MD, Goga, A, Ramanujam, N.
In Vivo Optical Metabolic Imaging of Long-Chain Fatty Acid Uptake in Orthotopic Models of Triple-Negative Breast Cancer.
Cancers (Basel). 2021 Jan 5;13(1):148-134. doi: 10.3390/cancers13010148
pubmed.ncbi.nlm.nih.gov/33466329/
Komoll, RM, Hu Q, Olarewaju O, von Döhlen L, Yuan Q, Xie Y, Tsay HC, Daon J, Qin R, Manns MP, Sharma AD, Goga A, Ott M, Balakrishnan A.
MicroRNA-342-3p is a potent tumor suppressor in hepatocellular carcinoma.
J Hepatol. 2021 Jan 74(1):122-134. doi: 10.1016/j.jhep.2020.07.039. Epub 2020 Jul 30
pubmed.ncbi.nlm.nih.gov/32738449/
Rohrberg J, Van de Mark D, Amouzgar M, Lee JV, Taileb M, Corella A, Klinic S, Williams J, Jokisch M, Camarda R, Balakrishnan S, Shankar R, Zhou A, Chang AN, Chen B, Rugo,HS, Dumont S, Goga A.
MYC dysregulates mitosis, revealing cancer vulnerabilities.
Cell Reports. 2020 Mar10 30(10):3368-3382. doi: 10.1016/j.celrep.2020.02.041
pubmed.ncbi.nlm.nih.gov/32160543/
Shah KN, Bhatt R, Rotow J, Rohrberg J, Olivas V, Wang VE, Hemmati G, Martins MM, Maynard A, Kuhn J, Galeas J, Donnella HJ, Kaushik S, Ku A, Dumont S, Krings G, Haringsma HJ, Robillard L, Simmons AD, Harding TC, McCormick F, Goga A, Blakely CM, Bivona TG, Bandyopadhyay S.
Aurora kinase A drives the evolution of resistance to third-generation EGFR inhibitors in lung cancer.
Nat Med. 2019 Jan 25(1):111-118. doi: 10.1038/s41591-018-0264-7.
pubmed.ncbi.nlm.nih.gov/30478424/
Fish, L, Zhang S, Yu JX, Culbertson B, Zhou AY, Goga A, Goodarzi, H.
Cancer cells exploit an orphan RNA to drive.
Nat Med. 2018 Nov;24(11):1743-1751. doi: 10.1038/s41589-018-0230-4. Epub 2018 Nov 5.
pubmed.ncbi.nlm.nih.gov/30397354/
Roy S, Hooiveld GJ, Seehawer M, Caruso S, Heinzmann F, Schneider AT, Frank AK, Cardenas DV, Sonntag R, Luedde M, Trautwein C, Stein I, Pikarsky E, Loosen S, Tacke F, Ringelhan M, Avsaroglu SK, Goga A, Buendia MA, Vucur M, Heikenwalder M, Zucman-Rossi J, Zender L, Roderburg C, Luedde T.
microRNA 193a-5p Regulates Levels of Nucleolar- and Spindle-Associated Protein 1 to Suppress Hepatocarcinogenesis.
Gastroenterology. 2018 Dec;155(6):1951-1966. doi: 10.1053/j.gastro.2018.08.032. Epub 2018 Aug 27.
pubmed.ncbi.nlm.nih.gov/30165047/
Donnella HJ, Webber JT, Levin RS, Camarda R, Momcilovic O, Bayani N, Shah KN, Korkola JE, Shokat KM, Goga A, Gordan JD, Bandyopadhyay S.
Kinome rewiring reveals AURKA limits PI3K-pathway inhibitor efficacy in breast cancer.
Nat Chem Biol. 2018 Aug;14(8):768-777. doi: 10.1038/s41589-018-0081-9. Epub 2018 Jun 25.
pubmed.ncbi.nlm.nih.gov/29942081/
Nguyen QH, Pervolarakis N, Blake K, Ma D, Davis RT, James N, Phung AT, Willey E, Kumar R, Jabart E, Driver I, Rock J, Goga A, Khan SA, Lawson DA, Werb Z, Kessenbrock K.
Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity.
Nat Commun. 2018 May 23;9(1):2028. doi: 10.1038/s41467-018-04334-1.
pubmed.ncbi.nlm.nih.gov/29795293/
Samson S, Northey JJ, Plaks V, Baas C, Dean I, LaBarge MA, Goga A, Van't Veer LJ, Weaver VM.
New Horizons in Advocacy Engaged Physical Sciences and Oncology Research.
Trends Cancer. 2018 Apr;4(4):260-264. doi: 10.1016/j.trecan.2018.02.002. Epub 2018 Mar 15.
pubmed.ncbi.nlm.nih.gov/29606307/
Dvir Aran, Roman Camarda, Justin Odegaard, Hyojung Paik, Boris Oskotsky, Gregor Krings, Andrei Goga, Marina Sirota & Atul J. Butte.
Comprehensive analysis of normal adjacent to tumor transcriptomes.
Nat Commun. 2017 Oct 20;8(1):1077. doi: 10.1038/s41467-017-01027-z.
pubmed.ncbi.nlm.nih.gov/29057876/
Shin PJ, Zhu Z, Camarda R, Bok RA, Zhou AY, Kurhanewicz J, Goga A, Vigneron DB.
Cancer recurrence monitoring using hyperpolarized 13C-pyruvate metabolic imaging in murine breast cancer model.
Magnetic resonance imaging. 2017; 43:105-109.
pubmed.ncbi.nlm.nih.gov/28716678/
Milshteyn E, von Morze C, Reed GD, Shang H, Shin PJ, Zhu Z, Chen HY, Bok R, Goga A, Kurhanewicz J, Larson PE, Vigneron DB.
Development of high resolution 3D hyperpolarized carbon-13 MR molecular imaging techniques.
Magnetic resonance imaging. 2017; 38:152-162.
pubmed.ncbi.nlm.nih.gov/28077268/
Anderton B, Camarda R, Balakrishnan S, Balakrishnan A, Kohnz RA, Lim L, Evason KJ, Momcilovic O, Kruttwig K, Huang Q, Xu G, Nomura DK, Goga A.
MYC-driven inhibition of the glutamate-cysteine ligase promotes glutathione depletion in liver cancer.
EMBO reports. 2017; 18(4):569-585.
pubmed.ncbi.nlm.nih.gov/28219903/
Kessenbrock K, Smith P, Steenbeek SC, Pervolarakis N, Kumar R, Minami Y, Goga A, Hinck L, Werb Z.
Diverse regulation of mammary epithelial growth and branching morphogenesis through noncanonical Wnt signaling.
Proceedings of the National Academy of Sciences of the United States of America. 2017; 114(12):3121-3126.
pubmed.ncbi.nlm.nih.gov/28270600/
Camarda R, Williams J, Goga A.
In Vivo Reprogramming of Cancer Metabolism by MYC.
Frontiers in Cell and Developmental Biology. 2017; 5:35.
pubmed.ncbi.nlm.nih.gov/28443280/
Horiuchi D, Camarda R, Zhou AY, Yau C, Momcilovic O, Balakrishnan S, Corella AN, Eyob H, Kessenbrock K, Lawson DA, Marsh LA, Anderton BN, Rohrberg J, Kunder R, Bazarov AV, Yaswen P, McManus MT, Rugo HS, Werb Z, Goga A.
PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression.
Nature Medicine. 2016; 22(11):1321-1329.
pubmed.ncbi.nlm.nih.gov/27775705/
Kohnz RA, Roberts LS, DeTomaso D, Bideyan L, Yan P, Bandyopadhyay S, Goga A, Yosef N, Nomura DK.
Protein Sialylation Regulates a Gene Expression Signature that Promotes Breast Cancer Cell Pathogenicity.
ACS Chemical Biology. 2016; 11(8):2131-9.
pubmed.ncbi.nlm.nih.gov/27380425/
Louie SM, Grossman EA, Crawford LA, Ding L, Camarda R, Huffman TR, Miyamoto DK, Goga A, Weerapana E, Nomura DK.
GSTP1 Is a Driver of Triple-Negative Breast Cancer Cell Metabolism and Pathogenicity.
Cell Chemical Biology. 2016; 23(5):567-578.
pubmed.ncbi.nlm.nih.gov/27185638/
Camarda R, Zhou AY, Kohnz RA, Balakrishnan S, Mahieu C, Anderton B, Eyob H, Kajimura S, Tward A, Krings G, Nomura DK, Goga A. Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer.
Nature Medicine. 2016; 22(4):427-32.
pubmed.ncbi.nlm.nih.gov/26950360/
Caswell JL, Camarda R, Zhou AY, Huntsman S, Hu D, Brenner SE, Zaitlen N, Goga A, Ziv E.
Multiple breast cancer risk variants are associated with differential transcript isoform expression in tumors.
Human Molecular Genetics. 2015; 24(25):7421-31.
pubmed.ncbi.nlm.nih.gov/26472073/
Wang ES, Reyes NA, Melton C, Huskey NE, Momcilovic O, Goga A, Blelloch R, OakesSA.
Fas-Activated Mitochondrial Apoptosis Culls Stalled Embryonic Stem Cells to Promote Differentiation.
Current Biology : CB. 2015; 25(23):3110-8.
pubmed.ncbi.nlm.nih.gov/26585277/
Lawson DA, Bhakta NR, Kessenbrock K, Prummel KD, Yu Y, Takai K, Zhou A, Eyob H,Balakrishnan S, Wang CY, Yaswen P, Goga A, Werb Z.
Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells.
Nature. 2015; 526(7571):131-5.
pubmed.ncbi.nlm.nih.gov/26416748/
Kohnz RA, Mulvihill MM, Chang JW, Hsu KL, Sorrentino A, Cravatt BF, Bandyopadhyay S, Goga A, Nomura DK.
Activity-Based Protein Profiling of Oncogene-Driven Changes in Metabolism Reveals Broad Dysregulation of PAFAH1B2 and 1B3 in Cancer.
ACS Chemical Biology. 2015; 10(7):1624-30.
pubmed.ncbi.nlm.nih.gov/25945974/
Brondfield S, Umesh S, Corella A, Zuber J, Rappaport AR, Gaillard C, Lowe SW, Goga A, Kogan SC.
Direct and indirect targeting of MYC to treat acute myeloid leukemia.
Cancer Chemotherapy and Pharmacology. 2015; 76(1):35-46.
pubmed.ncbi.nlm.nih.gov/25956709/
Evason KJ, Francisco MT, Juric V, Balakrishnan S, Lopez Pazmino Mdel P, Gordan JD, Kakar S, Spitsbergen J, Goga A, Stainier DY.
Identification of Chemical Inhibitors of β-Catenin-Driven Liver Tumorigenesis in Zebrafish.
PLoS Genetics. 2015; 11(7):e1005305.
pubmed.ncbi.nlm.nih.gov/26134322/
Huskey NE, Guo T, Evason KJ, Momcilovic O, Pardo D, Creasman KJ, Judson RL, Blelloch R, Oakes SA, Hebrok M, Goga A.
CDK1 inhibition targets the p53-NOXA-MCL1 axis, selectively kills embryonic stem cells, and prevents teratoma formation.
Stem Cell Reports. 2015; 4(3):374-89.
pubmed.ncbi.nlm.nih.gov/25733019/
Martins MM, Zhou AY, Corella A, Horiuchi D, Yau C, Rakshandehroo T, Gordan JD, Levin RS, Johnson J, Jascur J, Shales M, Sorrentino A, Cheah J, Clemons PA, Shamji AF, Schreiber SL, Krogan NJ, Shokat KM, McCormick F, Goga A, Bandyopadhyay S.
Linking tumor mutations to drug responses via a quantitative chemical-genetic interaction map.
Cancer Discovery. 2015; 5(2):154-67.
pubmed.ncbi.nlm.nih.gov/25501949/
Patton JG, Franklin JL, Weaver AM, Vickers K, Zhang B, Coffey RJ, Ansel KM, Blelloch R, Goga A, Huang B, L'Etoille N, Raffai RL, Lai CP, Krichevsky AM, Mateescu B, Greiner VJ, Hunter C, Voinnet O, McManus MT.
Biogenesis, delivery, and function of extracellular RNA.
Journal of Extracellular Vesicles. 2015; 4:27494.
pubmed.ncbi.nlm.nih.gov/26320939/
Hoellein A, Fallahi M, Schoeffmann S, Steidle S, Schaub FX, Rudelius M, Laitinen I, Nilsson L, Goga A, Peschel C, Nilsson JA, Cleveland JL, Keller U.
Myc-induced SUMOylation is a therapeutic vulnerability for B-cell lymphoma.
Blood. 2014; 124(13):2081-90.
pubmed.ncbi.nlm.nih.gov/25143484/
Benjamin DI, Louie SM, Mulvihill MM, Kohnz RA, Li DS, Chan LG, Sorrentino A, Bandyopadhyay S, Cozzo A, Ohiri A, Goga A, Ng SW, Nomura DK.
Inositol phosphate recycling regulates glycolytic and lipid metabolism that drives cancer aggressiveness.
ACS Chemical Biology. 2014; 9(6):1340-50.
pubmed.ncbi.nlm.nih.gov/24738946/
Chien AJ, Munster PN, Melisko ME, Rugo HS, Park JW, Goga A, Auerback G, Khanafshar E, Ordovas K, Koch KM, Moasser MM.
Phase I dose-escalation study of 5-day intermittent oral lapatinib therapy in patients with human epidermal growth factor receptor 2-overexpressing breast cancer.
Journal of Clinical Oncology : official journal of the American Society of Clinical Oncology. 2014; 32(14):1472-9.
pubmed.ncbi.nlm.nih.gov/24711549/
Balko JM, Giltnane JM, Wang K, Schwarz LJ, Young CD, Cook RS, Owens P, Sanders ME, Kuba MG, Sánchez V, Kurupi R, Moore PD, Pinto JA, Doimi FD, Gómez H, Horiuchi D, Goga A, Lehmann BD, Bauer JA, Pietenpol JA, Ross JS, Palmer GA, Yelensky R,Cronin M, Miller VA, Stephens PJ, Arteaga CL.
Molecular profiling of the residual disease of triple-negative breast cancers after neoadjuvant chemotherapy identifies actionable therapeutic targets.
Cancer Discovery. 2014; 4(2):232-45.
pubmed.ncbi.nlm.nih.gov/24356096/
Lim L, Balakrishnan A, Huskey N, Jones KD, Jodari M, Ng R, Song G, Riordan J, Anderton B, Cheung ST, Willenbring H, Dupuy A, Chen X, Brown D, Chang AN, Goga A.
MicroRNA-494 within an oncogenic microRNA megacluster regulates G1/S transition in liver tumorigenesis through suppression of mutated in colorectal cancer.
Hepatology (Baltimore, Md.). 2014; 59(1):202-15.
pubmed.ncbi.nlm.nih.gov/23913442/
Swisher CL, Larson PE, Kruttwig K, Kerr AB, Hu S, Bok RA, Goga A, Pauly JM, Nelson SJ, Kurhanewicz J, Vigneron DB.
Quantitative measurement of cancer metabolism using stimulated echo hyperpolarized carbon-13 MRS.
Magnetic resonance in medicine. 2014; 71(1):1-11.
pubmed.ncbi.nlm.nih.gov/23412881/
Horiuchi D, Anderton B, Goga A.
Taking on challenging targets: making MYC druggable.
American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Meeting. 2014; :e497-502.
pubmed.ncbi.nlm.nih.gov/24857145/
Olive V, Sabio E, Bennett MJ, De Jong CS, Biton A, McGann JC, Greaney SK, Sodir NM, Zhou AY, Balakrishnan A, Foth M, Luftig MA, Goga A, Speed TP, Xuan Z, Evan GI, Wan Y, Minella AC, He L.
A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis.
eLife. 2013; 2:e00822.
pubmed.ncbi.nlm.nih.gov/24137534/
Juang BT, Gu C, Starnes L, Palladino F, Goga A, Kennedy S, L'Etoile ND.
Endogenous nuclear RNAi mediates behavioral adaptation to odor.
Cell. 2013; 154(5):1010-22.
pubmed.ncbi.nlm.nih.gov/23993094/
Upton JP, Wang L, Han D, Wang ES, Huskey NE, Lim L, Truitt M, McManus MT, Ruggero D, Goga A, Papa FR, Oakes SA.
IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2.
Science (New York, N.Y.). 2012; 338(6108):818-22.
pubmed.ncbi.nlm.nih.gov/23042294/
Amin DN, Sergina N, Lim L, Goga A, Moasser MM.
HER3 signalling is regulated through a multitude of redundant mechanisms in HER2-driven tumour cells.
The Biochemical Journal. 2012; 447(3):417-25.
pubmed.ncbi.nlm.nih.gov/22853430/
Horiuchi D, Huskey NE, Kusdra L, Wohlbold L, Merrick KA, Zhang C, Creasman KJ,Shokat KM, Fisher RP, Goga A.
Chemical-genetic analysis of cyclin dependent kinase 2 function reveals an important role in cellular transformation by multiple oncogenic pathways.
Proceedings of the National Academy of Sciences of the United States of America. 2012; 109(17):E1019-27.
pubmed.ncbi.nlm.nih.gov/22474407/
Horiuchi D, Kusdra L, Huskey NE, Chandriani S, Lenburg ME, Gonzalez-Angulo AM, Creasman KJ, Bazarov AV, Smyth JW, Davis SE, Yaswen P, Mills GB, Esserman LJ, Goga A.
MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition.
The Journal of Experimental Medicine. 2012; 209(4):679-96.
pubmed.ncbi.nlm.nih.gov/22430491/
von Morze C, Larson PE, Hu S, Yoshihara HA, Bok RA, Goga A, Ardenkjaer-Larsen JH, Vigneron DB.
Investigating tumor perfusion and metabolism using multiple hyperpolarized (13)C compounds: HP001, pyruvate and urea.
Magnetic resonance imaging. 2012; 30(3):305-11.
pubmed.ncbi.nlm.nih.gov/22430491/
Hu S, Balakrishnan A, Bok RA, Anderton B, Larson PE, Nelson SJ, Kurhanewicz J, Vigneron DB, Goga A.
13C-pyruvate imaging reveals alterations in glycolysis that precede c-Myc-induced tumor formation and regression.
Cell Metabolism. 2011; 14(1):131-42.
pubmed.ncbi.nlm.nih.gov/21723511/
Merrick KA, Wohlbold L, Zhang C, Allen JJ, Horiuchi D, Huskey NE, Goga A, Shokat KM, Fisher RP.
Switching Cdk2 on or off with small molecules to reveal requirements in human cell proliferation.
Molecular cell. 2011; 42(5):624-36.
pubmed.ncbi.nlm.nih.gov/21658603/
Chow EK, Zhang XQ, Chen M, Lam R, Robinson E, Huang H, Schaffer D, Osawa E, Goga A, Ho D.
Nanodiamond therapeutic delivery agents mediate enhanced chemoresistant tumor treatment.
Science Translational Medicine. 2011; 3(73):73ra21.
pubmed.ncbi.nlm.nih.gov/21389265/
von Morze C, Larson PE, Hu S, Keshari K, Wilson DM, Ardenkjaer-Larsen JH, Goga A, Bok R, Kurhanewicz J, Vigneron DB.
Imaging of blood flow using hyperpolarized [(13)C]urea in preclinical cancer models.
Journal of Magnetic Resonance Imaging : JMRI. 2011; 33(3):692-7.
pubmed.ncbi.nlm.nih.gov/21563254/
Swarbrick A, Woods SL, Shaw A, Balakrishnan A, Phua Y, Nguyen A, Chanthery Y, Lim L, Ashton LJ, Judson RL, Huskey N, Blelloch R, Haber M, Norris MD, Lengyel P, Hackett CS, Preiss T, Chetcuti A, Sullivan CS, Marcusson EG, Weiss W, L'Etoile N, Goga A.
miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN-amplified neuroblastoma.
Nature Medicine. 2010; 16(10):1134-40.
pubmed.ncbi.nlm.nih.gov/20871609/
den Hollander J, Rimpi S, Doherty JR, Rudelius M, Buck A, Hoellein A, Kremer M, Graf N, Scheerer M, Hall MA, Goga A, von Bubnoff N, Duyster J, Peschel C, Cleveland JL, Nilsson JA, Keller U.
Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state.
Blood. 2010; 116(9):1498-505.
pubmed.ncbi.nlm.nih.gov/20519624/
Yang D, Liu H, Goga A, Kim S, Yuneva M, Bishop JM.
Therapeutic potential of a synthetic lethal interaction between the MYC proto-oncogene and inhibition of aurora-B kinase.
Proceedings of the National Academy of Sciences of the United States of America. 2010; 107(31):13836-41.
pubmed.ncbi.nlm.nih.gov/20643922/
Lee JI, O'Halloran DM, Eastham-Anderson J, Juang BT, Kaye JA, Scott Hamilton O, Lesch B, Goga A, L'Etoile ND.
Nuclear entry of a cGMP-dependent kinase converts transient into long-lasting olfactory adaptation.
Proceedings of the National Academy of Sciences of the United States of America. 2010; 107(13):6016-21.
pubmed.ncbi.nlm.nih.gov/20220099/
Hu S, Lustig M, Balakrishnan A, Larson PE, Bok R, Kurhanewicz J, Nelson SJ, Goga A, Pauly JM, Vigneron DB.
3D compressed sensing for highly accelerated hyperpolarized (13)C MRSI with in vivo applications to transgenic mouse models of
cancer.
Magnetic resonance in medicine. 2010; 63(2):312-21.
pubmed.ncbi.nlm.nih.gov/20017160/
Huang TH, Wu F, Loeb GB, Hsu R, Heidersbach A, Brincat A, Horiuchi D, Lebbink RJ, Mo YY, Goga A, McManus MT.
Up-regulation of miR-21 by HER2/neu signaling promotes cell invasion.
The Journal of biological chemistry. 2009; 284(27):18515-24.
pubmed.ncbi.nlm.nih.gov/19419954/
Kaye JA, Rose NC, Goldsworthy B, Goga A, L'Etoile ND.
A 3'UTR pumilio-binding element directs translational activation in olfactory sensory neurons.
Neuron. 2009; 61(1):57-70.
pubmed.ncbi.nlm.nih.gov/19146813/
Cairo S, Armengol C, De Reyniès A, Wei Y, Thomas E, Renard CA, Goga A, Balakrishnan A, Semeraro M, Gresh L, Pontoglio M, Strick-Marchand H, Levillayer F, Nouet Y, Rickman D, Gauthier F, Branchereau S, Brugières L, Laithier V, Bouvier R, Boman F, Basso G, Michiels JF, Hofman P, Arbez-Gindre F, Jouan H, Rousselet-Chapeau MC, Berrebi D, Marcellin L, Plenat F, Zachar D, Joubert M, Selves J, Pasquier D, Bioulac-Sage P, Grotzer M, Childs M, Fabre M, Buendia MA.
Hepatic stem-like phenotype and interplay of Wnt/beta-catenin and Myc signaling in aggressive childhood liver cancer.
Cancer Cell. 2008; 14(6):471-84.
pubmed.ncbi.nlm.nih.gov/19061838/
Goga A, Benz C.
Anti-oncomir suppression of tumor phenotypes.
Molecular interventions. 2007; 7(4):199-202, 180.
pubmed.ncbi.nlm.nih.gov/17827440/
Goga A, Yang D, Tward AD, Morgan DO, Bishop JM.
Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC.
Nature Medicine. 2007; 13(7):820-7.
pubmed.ncbi.nlm.nih.gov/17589519/
Scott GK, Goga A, Bhaumik D, Berger CE, Sullivan CS, Benz CC.
Coordinate suppression of ERBB2 and ERBB3 by enforced expression of micro-RNA miR-125a or miR-125b.
The Journal of Biological Chemistry. 2007; 282(2):1479-86.
pubmed.ncbi.nlm.nih.gov/17110380/
Yang D, Goga A, Bishop JM.
RNA interference (RNAi) with RNase III-prepared siRNAs.
Methods in molecular biology (Clifton, N.J.). 2004; 252:471-82.
pubmed.ncbi.nlm.nih.gov/15017072/
Yang D, Buchholz F, Huang Z, Goga A, Chen CY, Brodsky FM, Bishop JM.
Short RNA duplexes produced by hydrolysis with Escherichia coli RNase III mediate effective RNA interference in mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America. 2002; 99(15):9942-7.
pubmed.ncbi.nlm.nih.gov/12096193/
Prior to Joining UCSF:
Moro M, Walkenhorst J, Goga A, Witte ON, Superti-Furga G.
A functional screen for regulators of the c-Abl protein tyrosine kinase.
Leukemia. 1997; 11 Suppl 3:313-5.
pubmed.ncbi.nlm.nih.gov/9209375/
Golub TR, Goga A, Barker GF, Afar DE, McLaughlin J, Bohlander SK, Rowley JD, Witte ON, Gilliland DG.
Oligomerization of the ABL tyrosine kinase by the Ets protein TEL in human leukemia.
Molecular and cellular biology. 1996; 16(8):4107-16.
pubmed.ncbi.nlm.nih.gov/8754809/
Walkenhorst J, Goga A, Witte ON, Superti-Furga G.
Analysis of human c-Abl tyrosine kinase activity and regulation in S. pombe.
Oncogene. 1996; 12(7):1513-20.
pubmed.ncbi.nlm.nih.gov/8622867/
Goga A, McLaughlin J, Afar DE, Saffran DC, Witte ON.
Alternative signals to RAS for hematopoietic transformation by the BCR-ABL oncogene.
Cell. 1995; 82(6):981-8.
pubmed.ncbi.nlm.nih.gov/7553858/
Goga A, Liu X, Hambuch TM, Senechal K, Major E, Berk AJ, Witte ON, Sawyers CL.
p53 dependent growth suppression by the c-Abl nuclear tyrosine kinase.
Oncogene. 1995; 11(4):791-9.
pubmed.ncbi.nlm.nih.gov/7651743/
Cohen L, Mohr R, Chen YY, Huang M, Kato R, Dorin D, Tamanoi F, Goga A, Afar D, Rosenberg N.
Transcriptional activation of a ras-like gene (kir) by oncogenic tyrosine kinases.
Proceedings of the National Academy of Sciences of the United States of America. 1994; 91(26):12448-52.
pubmed.ncbi.nlm.nih.gov/7809057/
Afar DE, Goga A, McLaughlin J, Witte ON, Sawyers CL.
Differential complementation of Bcr-Abl point mutants with c-Myc.
Science (New York, N.Y.). 1994; 264(5157):424-6.
pubmed.ncbi.nlm.nih.gov/8153630/
Sawyers CL, McLaughlin J, Goga A, Havlik M, Witte O.
The nuclear tyrosine kinase c-Abl negatively regulates cell growth.
Cell. 1994; 77(1):121-31.
pubmed.ncbi.nlm.nih.gov/7512450/
Afar DE, Goga A, Cohen L, Sawyers CL, McLaughlin J, Mohr RN, Witte ON.
Genetic approaches to defining signaling by the CML-associated tyrosine kinase BCR-ABL.
Cold Spring Harbor symposia on quantitative biology. 1994; 59:589-94.
pubmed.ncbi.nlm.nih.gov/7587117/
Goga A, McLaughlin J, Pendergast AM, Parmar K, Muller A, Rosenberg N, Witte ON.
Oncogenic activation of c-ABL by mutation within its last exon.
Molecular and Cellular biology. 1993; 13(8):4967-75.
pubmed.ncbi.nlm.nih.gov/8336729/